Will a M+B key 8x Sata card work in a M key socket?

Will a M+B key 8x Sata card work in a M key socket? m 2 2280 slot
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m2 sata vs nvme slot Acer ; Acer Aspire VX 15 , 1x 2280 PCIe NVMe ; Acer ConceptD 5 , 2x 2280 NVMe slot ; Acer ConceptD 7 Pro , 2x

m2 slot pc Drives that use NVMe were introduced in 2013 to attach to the Peripheral Component Interconnect Express slot directly on a motherboard is a slot that can interface with SATA , PCI Express